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Rheumatism researchers in Leipzig discover new mechanism
Scientists at Leipzig University Medicine have discovered a new mechanism that triggers an acute inflammatory reaction in rheumatic diseases. A simultaneous lack of oxygen and glucose leads to metabolic changes in cells of the innate immune system that disrupt the anchoring of proteins in the cell membrane and activate the inflammasome complex. This releases pro-inflammatory messenger substances and increases tissue inflammation. These findings could provide new approaches for the treatment of rheumatism. The results were published in the journal "Science Signaling".
Tue/Jul/2024
Patients with rare autoinflammatory syndromes that show an increased tendency to inflammation under mild oxygen deprivation were examined. Various cell and molecular biological methods as well as modern microscopic imaging techniques were used. Study leader Prof. Dr Ulf Wagner emphasises that the results could open up new diagnostic and therapeutic possibilities. Further studies will investigate the influence of disrupted protein anchoring in cell membranes on the inflammatory reaction in rheumatoid arthritis in more detail.
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